Articles

Notes on biomarkers, prevention, ageing, and biomedical data science.

Short notes on biomarkers, prevention, ageing, and biomedical data science.

Infographic: STRING-GCN recovers known IPF targets at AUPRC 0.322 versus 0.305 for XGBoost and 0.098 for a GCN without edges

Drug target identification for idiopathic pulmonary fibrosis (IPF) via geometric deep learning on a knowledge graph

Machine learning
Target identification
Knowledge Graph
Neural Network

A STRING GCN recovers known clinical-stage idiopathic pulmonary fibrosis (IPF) targets at AUPRC 0.322, versus 0.305 for XGBoost and 0.098 for a GCN without edges.

2026-08-16
14 min
Infographic comparing age gap, age speed, and age acceleration

Age gap, age speed, and age acceleration are not the same thing

Ageing
Biomarkers

High school physics explains why many biological age clocks use the word acceleration for what is really an age gap.

2026-08-01
4 min
Infographic: elevated Alzheimer's biomarkers and diet still matter for dementia risk

Elevated Alzheimer’s biomarkers do not mean the prevention window is closed

Biomarkers
Dementia
Nutrition

A Swedish cohort study suggests diet quality may still matter after blood biomarkers linked to Alzheimer’s pathology are already elevated.

2026-07-26
2 min
Summary graphic for the DHA brain delivery trial

Omega-3 supplementation did not improve cognition in a two-year trial

Causation
Dementia
Nutrition

A randomised DHA trial shows why association and causation are not the same thing for brain health claims.

2026-07-18
3 min
Illustration separating risk detection, biological interpretation, and intervention evidence

A biomarker of disease risk is not the same as an intervention target

Biomarkers
Causation
Prevention

ATBC and SELECT show why a risk signal does not automatically become an actionable intervention.

2026-07-10
3 min
Infographic: using routine blood data and AI to triage possible womb cancer referrals

Reading routine blood data before invasive procedures

Biomarkers
Machine learning
Prevention

An NHS AI blood-test trial for possible womb cancer shows how earlier risk routing can reduce unnecessary investigations.

2026-07-09
3 min
Infographic on prolonged sitting and cancer risk

Your cancer risk rises with long sitting time

Prevention

A UK Biobank accelerometer study links prolonged uninterrupted sitting with higher cancer death hazard, without claiming causation.

2026-07-09
2 min
Diagram separating diagnostic tests, screening tests, and risk assessment tools

Diagnostic test, screening test, and risk assessment tool are not interchangeable

Diagnostics
Prevention

Three terms that get mixed up in investor pitches, clinics, and science conversations, and why the distinction matters.

2026-04-22
3 min
Graphic on open-weight LLM risk and regulation

Frontier open-source and open-weight LLMs should be heavily regulated

Opinion

Powerful model weights without control create a safety gap that policy cannot close fast enough.

2026-02-17
3 min
PEACE and LOVE injury recovery framework

Injured during sport? Break up with RICE, and find some PEACE & LOVE

Sports medicine

The BJSM PEACE & LOVE framework is a modern, evidence-aligned alternative to ice-and-rest for soft-tissue injuries.

2026-01-22
2 min
Infographic on fibre intake gaps and practical food swaps

If you want one health priority for 2026, make it fibre

Nutrition
Prevention
Public health

Most adults miss fibre targets, yet higher intake tracks with lower mortality, cardiometabolic disease, and colorectal cancer risk.

2026-01-18
3 min
Infographic linking major pandemics to animal exploitation

Six of the worst modern pandemics share a common thread: animal exploitation

Public health

Spillover history from COVID-19 to 1918 influenza, and why pandemic prevention starts with high-risk animal-human interfaces.

2025-08-30
3 min
Infographic: Alzheimer's risk testing options with relative cost

How to know your Alzheimer’s risk

Biomarkers
Dementia
Diagnostics

A practical catalogue of DNA, blood, CSF, PET and MRI options with regulatory status, geography and approximate price.

2025-07-11
3 min
Map of NCD deaths by WHO region

43 million chronic-disease deaths in 2021, and most were preventable

Prevention
Public health

WHO data on NCD deaths by region and country, after a question at the CSEM Startup Night.

2025-07-08
2 min
Graphic on Alzheimer's risk awareness and prevention levers

People do want to know their Alzheimer’s risk

Biomarkers
Dementia
Prevention

Survey evidence, seven levers that can cut risk, and why earlier insight only helps if it opens a prevention conversation.

2025-07-08
3 min
Illustration linking vaccines and dementia risk reduction

Vaccines can cut dementia risk by about 35%

Dementia
Prevention

Routine adult vaccines look like a low-cost longevity play through trained immunity, pathogen control, and vascular protection.

2025-06-15
1 min
Illustration comparing precision and accuracy

Why I stopped using precision and accuracy for binary classification

Machine learning
Statistics

Three failure modes for PPV, accuracy, F-score and Youden’s J, and why the Phi coefficient / Matthews correlation coefficient is more robust.

2023-01-19
7 min
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